God created the heavens, the earth, and mankind [Genesis 1–2], but man sinned against God and was therefore exiled from His presence [Genesis 3]. One day, the seed of the woman will crush the head of the serpent, setting right everything “And I will put enmity Between you and the woman, And between your seed and her seed; He shall bruise you on the head, And you shall bruise him on the heel.” [Genesis 3:15].
The rest of the book of Genesis traces this seed: through Adam and Eve’s son Seth [Genesis 5], through Noah and his family [Genesis 6–10], and then finally to Abraham and his offspring [Genesis 12]. God confirms this by making great promises to Abraham of blessing, land, and offspring
” 1 Now the Lord said to Abram, “Go forth from your country, And from your relatives And from your father’s house, To the land which I will show you;
2 And I will make you a great nation, And I will bless you, And make your name great; And so you shall be a blessing;
3 And I will bless those who bless you, And the one who curses you I will curse. And in you all the families of the earth will be blessed.” [Genesis 12:1-3]. God begins to fulfill these promises through the birth of Isaac [Genesis 21].
Chapter 25 marks a major transition in the book of Genesis. Since chapter 12, the focus has primarily been on Abraham and his covenant with God. The hope of redemption, the hope that God will one day set all things right through the seed of the woman, carries on through Isaac. Therefore, Genesis 25 ends with these words: “After the death of Abraham, God blessed Isaac his son”.
Note: These eight parts on Genesis 25-27 benefit from the WinterDailyDevotional2018-19